Pāli Dictionary
doctrine
悩（のう）；絶望；激しい精神的苦痛（不幸に遭遇した際に生じる強烈な心の苦しみ。愁・悲・苦・憂と並列される）
despair; extreme mental affliction; tribulation (specifically the intense mental suffering and distress arising from misfortune, often listed alongside sorrow, lamentation, pain, and grief)
AN 4.122
idha, bhikkhave, ekacco kulaputto saddhā agārasmā anagāriyaṃ pabbajito hoti, otiṇṇo'mhi jātiyā jarāya maraṇena sokehi paridevehi dukkhehi domanassehi upāyāsehi, dukkh'otiṇṇo dukkhapareto.
MN 38
taṇhāpaccayā upādānaṃ, upādānapaccayā bhavo, bhavapaccayā jāti, jātipaccayā jarāmaraṇaṃ soka-parideva-dukkha-domanass'upāyāsā sambhavanti
mind
苛立ち；立腹；心の動揺（いらいらして怒りやすい心の状態）
irritation; annoyance; internal unrest; being easily upset (a state of mind characterized by excitability and frustration)
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